Nature

A unique mouse model for succinic semialdehyde dehydrogenase deficiency with implications for gamma hydroxybutyrate intoxication

In a recently developed mouse model, both the GABA B receptor antagonist CPG 35348 and taurine, modify the neurotoxic effects of elevated gamma-hydroxybutyrate (GHB). This finding provides new scope ...
Nature

Relative Abuse Liability of GHB in Humans: A Comparison of Psychomotor, Subjective, and Cognitive Effects of Supratherapeutic Doses of Triazolam, Pentobarbital, and GHB

Although preclinical studies suggest that GHB has low likelihood for abuse, case reports indicate that GHB is abused. This study evaluated the relative abuse liability of GHB in 14 volunteers with ...