Ligand-induced protein allostery plays a central role in modulating cellular signalling pathways. Here using the conserved cyclic nucleotide-binding domain of protein kinase A’s (PKA) regulatory ...
The dynamics of the RNA polymerase II (Pol II) backtracking process is poorly understood. Scientists have now built a Markov State Model from extensive molecular dynamics simulations to identify ...
To initiate transcription, the holoenzyme (RNA polymerase [RNAP] in complex with σ factor) loads the promoter DNA via the flexible loading gate created by the clamp and β-lobe, yet their roles in DNA ...
Representative structures for each of the four metastable states identified by our Markov State Model (MSM; S1-S4) and connected by the top one pathway from the pre-translocation state (S1) to the ...
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