Get the opening NFL Week 18 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Jan. 3, 2026.

Matthew Stafford or Drake Maye? That’s the question that NFL MVP voters will be asking themselves after Week 18, but the betting market has picked a side.  Staf

SportsLine's model simulates every game 10,000 times and reveals its NFL picks today for spread, over/under and money line

Maye entered the 2025 campaign with lower expectations than Stafford. He exceeded the preseason thoughts around himself and the Patriots and then some. Winning a division title has to be rewarded along with stats. That's what Maye holds on his resume.

There is a lot to be excited about on the Week 18 NFL schedule, including the Seattle Seahawks taking on the San Francisco 49ers. If you're seeking additional betting info for Week 18 in the NFL, we have you covered with odds for each of the important games.

Ten of the 11 players with the best odds to be named 2026 NFL Most Valuable Player in the final week of the regular season are quarterbacks.

The SportsLine Projection Model has revealed its Pittsburgh vs. Baltimore picks for the AFC North crown on 'Sunday Night Football' in Week 18

There has been a ton of movement in the Offensive Rookie of the Year odds for the 2025 NFL season, but it appears that Carolina Panthers Tetairoa McMillan did e