Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies. Scientists have ...

Most mutations that cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a major study of human protein variants that was published in Nature ...

The Human Domainome 1—the largest library of human protein variants—reveals the cause of certain genetic disorders, paving the way for personalized medicines. “We measured every possible mutation in ...

The SWI/SNF Ig-Fold for Transcription Factor Interactions or 'SWIFT' domain on mSWI/SNF chromatin remodeling complexes engage ...

Unstable proteins are the main drivers of many different heritable diseases, according to a new study, including genetic disorders responsible for the formation of cataracts, and different types of ...

Protein has muscled its way to the center of the American plate, popping up everywhere from snack bars to ice cream. Once the domain of bodybuilders and keto diets, protein-focused eating has gone ...

A selective protein degradation system known as Golgi membrane-associated degradation (GOMED), which identifies and removes ...