Molecular dynamics simulations calculate the structure of p53m and its binding interfaces with p53-R175H and CRBN (a), and PAGE electrophoresis confirms the successful connection between p53m-DA and ...
A 3D virtual model of the PKMYT1–PROTAC–CRBN ternary complex depicting how Insilico Medicine’s bifunctional proteolysis-targeting chimera (PROTAC) D16-M1P2 (shown in yellow) inhibits ...
This article and associated images are based on a poster originally authored by Leif, F., Hsia, O., Cowan, A.D., Iso, K. and Ciulli, A. and presented at ELRIG Drug Discovery 2025 in affiliation with ...
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