Faithful bypass of replication forks encountering obstructive DNA lesions is essential to prevent fork collapse and cell death. PrimPol is a new human primase and translesion polymerase that is able ...
PrimPol is the latest polymerase cloned from the human genome. The enzyme displays novel properties with great potential for application in the field of DNA sequencing and amplification. The work has ...
DNA G-quadruplexes (G4) are structures formed at guanine-rich sequences, with the capacity to impede DNA replication. Factors such as the helicase Fanconi anaemia group J (FANCJ) and the polymerase ...
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