The median time to reach a diagnosis of ATTR-CM from the time of heart failure diagnosis was 490 days (1.3 years). There are clinically important delays between the incidence of heart failure and the ...

More than one-third of the elevated serum proteins reflected muscle fiber damage and leakage into the bloodstream. A large, reproducible set of blood-based protein biomarkers can reliably distinguish ...

Almost all (97%) of the patients with positive planar imaging and positive single-photon emission computed tomography findings were diagnosed with ATTR-CM. Single-photon emission computed tomography ...

Patients with ATTR-CM who experienced outpatient worsening heart failure had a 2.5-fold increased risk of mortality compared with those who did not. Outpatient worsening heart failure is an ...

Patients reported higher habitual levels of physical activity following the PR intervention, shifting from low to moderate activity levels. A 12-month supervised program of pulmonary rehabilitation ...

The diagnosis and management of CIDP are complex and best addressed by an interprofessional health care team that includes neurologists, neuromuscular specialists, physical medicine and rehabilitation ...

Overall, the life expectancy of patients with SCD is lower than that of persons without SCD. 1 However, life expectancy varies depending on the type of disease, treatments administered, and ...

ATTR-CM is a genetic condition characterized by the destabilization of transthyretin and subsequent misfolding and aggregation into amyloid fibrils that results in abnormal deposition of amyloid in ...

Patients with PAH who experience low levels of oxygen may have a poor quality of life, and vital organs may be compromised if these levels are not corrected. 6 Oxygen therapy can help patients ...

CF affects every racial and ethnic group and is currently estimated to afflict more than 30,000 individuals in the United States and at least 100,000 people worldwide. 1,2,5 1. Shteinberg M, Haq IJ, ...

Individuals with advanced liver disease may also experience significant weight loss due to nausea and poor appetite. Candidates for liver transplantation may need to gain weight to optimize surgical ...

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare acquired autoimmune neurological disorder in which both T-cell-mediated and humoral immune mechanisms target healthy myelinated ...