Loss functions and constraints improve sea surface height prediction

In order to understand currents, tides and other ocean dynamics, scientists need to accurately capture sea surface height, or ...
pharmaphorum

J&J abandons Alzheimer's antibody in setback for tau

Hopes that anti-tau drugs could join those targeting amyloid as treatments for Alzheimer's disease have been dented by the failure of a phase 2b trial of Johnson & Johnson's posdinemab. The AuTonomy ...
eLife

Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicity

Prefoldin 5 stabilises neuronal microtubules and suppresses Tau-mediated neurotoxicity, offering a potential therapeutic ...
Medical Xpress

Modified tau thwarts aggregation in neurodegenerative disease—while retaining its biological function

Tau binds to microtubules through a part of the tau protein in which a stretch of amino acids is repeated either three or four times. These versions of tau are known as 3R or 4R, respectively. In ...
Yahoo Lifestyle Singapore

We tried Singapore’s best-rated yong tau foo

I headed over to 90 Circular Road in search of 109 Yong Tau Foo, situated just minutes away from Boat Quay. This standalone eatery has amassed a total of 435 reviews, and has received 4.4 stars out of ...
ALZFORUM

After Tau Immunotherapy, Tangle Markers Tank in CSF, Plasma

In a small, open-label trial in people with mild to moderate, dominantly inherited Alzheimer’s disease (DIAD), the tau immunotherapy etalanetug almost abolished markers of neurofibrillary tangles in ...