Frontiers

Exploring the heterodimer MDM2/MDM4 interaction region uncovers high-affinity peptides for therapeutic p53-reactivation

Introduction: In the era of targeted therapies, molecules for the reactivation of the oncosuppressor p53 in human cancer have not yet reached FDA or EMA approval. Recently, the interaction region of ...
News Medical

BA.2.86 Omicron sub-variant shows high receptor affinity but moderate neutralization resistance

In a recent study published in the journal Nature, researchers investigated the receptor affinity and antigenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2.86. The ...
C&EN

Identifying the Phenotypes of Tumor-Derived Extracellular Vesicles Using Size-Coded Affinity Microbeads

Tumor-derived extracellular vesicle (tEV) biomarkers can reflect cancer cell phenotypes and have great potential for cancer diagnosis and treatment. However, tEVs display high heterogeneity, and rapid ...
C&EN

PPI-Affinity: A Web Tool for the Prediction and Optimization of Protein–Peptide and Protein–Protein Binding Affinity

Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany Core Facility Functional Peptidomics, Ulm University Medical Center, Ulm 89081, Germany Creative Commons (CC): This ...
Frontiers

Carbon Availability Modifies Temperature Responses of Heterotrophic Microbial Respiration, Carbon Uptake Affinity, and Stable Carbon Isotope Discrimination

Department of Ecology and Evolutionary Biology, Kansas Biological Survey, University of Kansas, Lawrence, KS, USA The chemostat system consisted of two 1.9 L Mason jars (Ball, USA), which were ...