C&EN

Integrated Machine Learning and Structure-Based Virtual Screening Identify Osimertinib as a TNIK Inhibitor for Idiopathic Pulmonary Fibrosis

Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macau 999078, China ...
C&EN

Integrating Machine Learning-Based Pose Sampling with Established Scoring Functions for Virtual Screening

Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria Christian Doppler Laboratory ...
Frontiers

Discovery of a novel binding pocket in PPARγ for partial agonists: structure-based virtual screening identifies ginsenoside Rg5 as a partial agonist promoting beige adipogenesis

Peroxisome proliferator-activated receptor gamma (PPARγ) is a key target for metabolic disorders that contribute to obesity and type 2 diabetes mellitus (T2DM). However, full agonists such as ...
Frontiers

Improved genetic algorithm based on Shapley value for a virtual machine scheduling model in cloud computing

1 School of Information and Intelligent Engineering, Nantong College of Science and Technology, Nantong, China 2 Faculty of Social, Business and Computer Sciences, Varna Free University, Varna, ...
Forbes

The Power Of Deep Observability In Facilitating VMware Migrations

Broadcom's acquisition of VMware has created a greater need for network observability solutions among VMware customers looking to migrate away from that platform. Broadcom’s acquisition of VMware in ...
marktechpost

FuXi-2.0: Advancement in Machine Learning ML-based Weather Forecasting for Practical Applications

ML models are increasingly used in weather forecasting, offering accurate predictions and reduced computational costs compared to traditional numerical weather prediction (NWP) models. However, ...