In silico antibody accessibility analysis indicates that ectodomain epitopes are transiently exposed, while MPER epitopes are virtually always occluded in the pre-fusion trimer.
Abstract: Drug-Target Affinity (DTA) prediction plays a crucial role in drug discovery, and accurate DTA prediction can significantly reduce the cost of drug development. While most studies focus on ...
Department of Computational Drug Discovery and Design, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-Ku, Tokyo 113-8510, Japan ...
Google DeepMind’s work with AlphaFold has been nothing short of a miracle, but it is computationally expensive. With that in mind, Apple researchers set off to develop an alternative method to use AI ...
Abstract: Protein-protein interactions (PPIs) play an indispensable role in understanding disease-causing mechanisms, and the basic laws of food and drugs on life. Contemporary research on this issue, ...
A team led by UT Southwestern Medical Center researchers has uncovered the atomic structure of a protein complex pivotal to the function of motile cilia, the hair-like structures extending from the ...
A three-decade-old competition that has spawned three Nobel laureates is becoming victim to the chaos at the National Institutes of Health. The Community Wide Experiment on the Critical Assessment of ...
Department of Materials Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, 6-3-1 Niijuku, Katsushika, Tokyo 125-8585, Japan Department of Materials Science and ...
Scientists have for the first time looked deep into the protein structure that may determine our vision - and discovered that it is much more dynamic than previously thought. RBP3 not only changes its ...
Proteins are the essential component behind nearly all biological processes, from catalyzing reactions to transmitting signals within cells. While advances like AlphaFold have transformed our ability ...
From forming muscle fibers to protecting us from disease, proteins play an essential role in almost all biological processes in humans and other life forms alike. There has been extraordinary progress ...
Strands of tubulin, a protein in the cell’s skeleton, photographed using a high-resolution microscopy Credit: NIH Image Gallery – CC BY-NC 2.0 via Flickr. A team of researchers that included ...
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